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Ethanol → Ethyl 2-(4-(cyclopropanecarbonyl)phenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 4-(Cyclopropylcarbonyl)benzeneacetic acid | HCID 193731 | — |
| 触媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | Ethyl 2-(4-(cyclopropanecarbonyl)phenyl)acetate | HCID 11218514 | 88% |
反応手順
Dissolve 4-(cyclopropylcarbonyl)benzeneacetic acid in ethanol (150 mL) containing concentrated sulfuric acid (10 drops). Stir 24 hours. Add triethylamine (2 mL) and concentrate the solution. Dissolve the residue in water/ethyl acetate. Wash the organic phase with saturated sodium hydrogen carbonate solution, dry over anhydrous magnesium sulfate and concentrate. Purify by silica gel chromatography (400 mL silica gel, 20% ethyl acetate/heptane as eluent) to give the title compound (7.0 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06700012B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-f0360d79b5a64416b111ea0c372ef3f1 |
| 出典メモ | uspto-grants-2004_03 |