化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 4-(2-Indanylamino)-5-isopropylthieno[2,3-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 2-Aminoindan hydrochloride | HCID 122764 | — |
| 反応物 | HCID 178439799 | HCID 178439799 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(2-Indanylamino)-5-isopropylthieno[2,3-d]pyrimidine | HCID 22719603 | 62.1% |
反応手順
Using 4-hydroxy-5-isopropylthieno[2,3-d]pyrimidine (200 mg, 1.03 mmol), phosphorus oxychloride (1.0 ml), 2-aminoindan hydrochloride (200 mg, 1.2 mmol), triethylamine (1.0 ml, 7.2 mmol) and dry ethanol (5 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (190 mg, 0.64 mmol) having the following physical properties:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06703421B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-10d44b48026c4aa6a2fc4f8b677a718c |
| 出典メモ | uspto-grants-2004_03 |