化工社化工社 化学情報印刷レポート · 研究参考用
1-Iodohexane → 5-(Hexyloxy)-2-methyl-1H-indole-3-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Iodohexane | HCID 12527 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | O-Desmethyl-N-deschlorobenzoyl Indomethacin | HCID 11310252 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-(Hexyloxy)-2-methyl-1H-indole-3-acetic acid | HCID 19935757 | 62% |
反応手順
To a solution of 5-hydroxy-2-methyl-1H-indole-3-acetic acid (7.17 g, 35.0 mmol) in methanol (40 mL) is added sodium methoxide (70 mmol). The solution is evaporated, dimethylformamide (40 mL) is added followed by hexyl iodide (35.0 mmol). After 2 days the solvent is removed and the residue is partitioned between ethyl acetate and pH=4 buffer. The organic layer is separated, dried over MgSO4 and evaporated to 8.6 g of a brown solid. Recrystallization from ethanol/water affords 6.23 g (62%) of white crystals, m.p. 65°-67° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05229516 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-1e2dbac9c99d4930a37317edb68511d2 |
| 出典メモ | uspto-grants-1993_07 |