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Myristyl bromide → 3-(Tetradecyloxy)benzenemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Myristyl bromide | HCID 8208 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-Hydroxyphenethyl alcohol | HCID 83404 | — |
| 触媒 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-(Tetradecyloxy)benzenemethanol | HCID 10041710 | 652.2% |
反応手順
A mixture of 66 g of 3-hydroxyphenethyl alcohol, 147.43 g of 1-bromotetradecane, 27.65 g of sodium hydroxide and 2.15 g of trioctylmethyl ammonium chloride in 400 ml of toluene was refluxed for 42 hours. The mixture was washed with water and the organic layer dried with magnesium sulfate. The solvent was removed in vacuo and the warm concentrate poured into 1 liter of hexanes. The resulting solid was washed with cold hexanes then dried giving 998.6 g of the desired compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05231091 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-1161c2df0c8046888a26a9778defb941 |
| 出典メモ | uspto-grants-1993_07 |