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Potassium Carbonate → N-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-N'-(2-methylpropyl)thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Isobutyl isothiocyanate | HCID 68960 | — |
| 反応物 | 2-(4-Methoxyphenyl)-1,3-dioxolane-2-methanamine hydrochloride | HCID 20271792 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-N'-(2-methylpropyl)thiourea | HCID 12833654 | 89.65% |
反応手順
A mixture of 22 parts of 2-(4-methoxyphenyl)-1,3-dioxolane-2-methanamine hydrochloride, 11.5 parts of 1-isothiocyanato-2-methylpropane, 20.7 parts of potassium carbonate and 200 parts of 2-propanol is stirred and refluxed for 3 hours. The reaction mixture is filtered while hot and the filtrate is evaporated. The solid residue is crystallized from a mixture of benzene and petroleumether. The product is filtered off and dried, yielding 26 parts (89.65%) of N-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-N'-(2-methylpropyl)thiourea; mp. 96° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04533550 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-82a1a1cef70c42ccbb4caa6c9fec2055 |
| 出典メモ | uspto-grants-1985_08 |