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Ethyl bromoacetate → Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6,7-Dichloro-1-benzothiophene-5-ol | HCID 13289997 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate | HCID 13289999 | 63.8% |
反応手順
A mixture of 3.6 g of 6,7-dichloro-5-hydroxybenzo[b]thiophene, 3.0 g of ethyl bromoacetate, 1.5 g of potassium carbonate and 40 ml of anhydrous dimethylformamide is stirred at 70°-80° for 16 hours. The cooled mixture is diluted with ice-water (200 g) and the solid collected by filtration. Recrystallization of the crude product from acetone-hexane gives 3.2 g of ethyl [(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate as yellowish needles, mp 92°-93°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04537976 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-1930dce74430403d89f3c7b8d41e4795 |
| 出典メモ | uspto-grants-1985_08 |