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Pyridine → Methyl 5-formyl-2-thiophenecarboxylate oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Methyl 5-formylthiophene-2-carboxylate | HCID 818924 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 5-formyl-2-thiophenecarboxylate oxime | HCID 86745040 | 72% |
反応手順
A solution of methyl 5-formyl-2-thiophenecarboxylate, prepared according to Example 10, (6.26 g, 36.78 mmoles), hydroxylamine hydrochloride (3.07 g, 44.14 mmoles) and pyridine (3.49 g, 44.14 mmoles) in 200 ml of ethanol was refluxed for 2 hours. The ethanol was removed in vacuo, the residue dissolved in ether and washed with water. The organic layer was dried (magnesium sulfate) and evaporated to a yellow solid. Trituration with a small amount of ether furnished the title compound as a white solid (4.93 g, 72%), m.p. 164°-7° C. Oxime Z:E ratio:(82:18).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05290802 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-038889dfe10f49509407368a4d81b8a3 |
| 出典メモ | uspto-grants-1994_03 |