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Ammonium Hydroxide → 4-Quinolinamine, 8-fluoro-N-(2-(4-phenyl-2-thiazolyl)ethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 4-Chloro-8-fluoroquinoline | HCID 2736587 | — |
| 反応物 | 2-(4-Phenyl-thiazol-2-yl)-ethylamine hydrochloride | HCID 16192921 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Quinolinamine, 8-fluoro-N-(2-(4-phenyl-2-thiazolyl)ethyl)- | HCID 198722 | 21.6% |
反応手順
To 1.0 g of 4-chloro-8-fluoroquinoline was added 2.6 g of 2-β-aminoethyl-4-phenylthiazole monohydrochloride. The mixture was stirred under nitrogen and heated to 170°-175° C. for one hour. The mixture was then cooled and 250 mL of a 50:50 mixture of ammonium hydroxide and water was added. The product was extracted into CH2Cl2, which was then concentrated to dryness. Recrystallizing from pentane/CH2Cl2 gave 0.410 g of the title product. Yield 21.6%. M.P. 134°-135° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05294622 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-7cdc42133eb64af7826d7baafe0a8044 |
| 出典メモ | uspto-grants-1994_03 |