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Triethylamine → 3,4-Difluoro-4'-ethoxytolan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,2-Difluoro-4-iodobenzene | HCID 2724444 | — |
| 反応物 | 1-Ethoxy-4-ethynylbenzene | HCID 2775124 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | 3,4-Difluoro-4'-ethoxytolan | HCID 67857987 | — |
反応手順
0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242618 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-c11e140ba9cd45de8bbf75d1cbd64d0a |
| 出典メモ | uspto-grants-1993_09 |