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4-Hydroxybenzaldehyde → (-)-N-(p-hydroxybenzylidene)-1-(p-bromophenyl)ethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybenzaldehyde | HCID 126 | — |
| 反応物 | (R)-4-bromo-alpha-methylbenzylamine | HCID 853000 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (-)-N-(p-hydroxybenzylidene)-1-(p-bromophenyl)ethylamine | HCID 135802981 | 100% |
反応手順
4.44 g (0.0222 mole) of (R)-(+)-1-(p-bromophenyl)ethylamine and 2.85 g (0.0233 mole) of p-hydroxybenzaldehyde were dissolved in 30 ml of ethyl alcohol, and the solution thus formed was stirred under reflux for 3 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and refined by a column chromatography using 30 g of silica gel to give 6.75 g of (-)-N-(p-hydroxybenzylidene)-1-(p-bromophenyl)ethylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05298660 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-c85c00e039224d0fbdfb183b9c19d456 |
| 出典メモ | uspto-grants-1994_03 |