関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione | HCID 11470572 | — |
| 反応物 | 1-(2,5-Difluorophenyl)piperazine | HCID 18545281 | — |
| 生成物 | HCID 57245937 | HCID 57245937 | 32% |
反応手順
A mixture of 1-(2,5-difluorophenyl)piperazine (20 mg, 0.10 mmol) and (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione (20 mg, 0.082 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (10.8 mg, 0.026 mmol, 32%): ESI-MS m/z 406 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06706716B2 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-81bb182d02b04dfa85b91303e5259195 |
|---|
| 出典メモ | uspto-grants-2004_03 |
|---|
