関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 5-Phenyloxindole | HCID 13301978 | — |
| 反応物 | 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde | HCID 22042114 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-[5-(3-Diethylamino-propyl)-1H-indol-2-ylmethylene]-5-phenyl-1,3-dihydro-indol-2-one | HCID 69586695 | 11.7% |
反応手順
A mixture of 5-phenyl-2-oxindole (41 mg, 0.19 mmol), 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde (50 mg, 0.19 mmol) and piperidine(0.1 mL) in ethanol (1 mL) was heated in a sealed tube at 95° C. for 20 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 10 mg (11 %) of the title compound as an orange crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06706709B2 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-05f3cb6007a04a2b9ea99cc0e1dd307b |
|---|
| 出典メモ | uspto-grants-2004_03 |
|---|
