化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → Dimethyl 3-(3-bromo-5-thienylmethoxy)phthalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | Dimethyl 4-hydroxyphthalate | HCID 89726 | — |
| 反応物 | (4-Bromo-2-thienyl)methanol | HCID 2795484 | — |
| 生成物 | Dimethyl 3-(3-bromo-5-thienylmethoxy)phthalate | HCID 20636310 | — |
反応手順
In a manner similar to that of Example 9(i), by reaction of 20 g (103 mmol) of (3-bromo-5-thienyl)methanol with 21.6 mL (155 mmol) of triethylamine and 8.8 mL (114 mmol) of methanesulphonyl chloride, followed by 500 mg (3.5 mmol) of sodium iodide, 14.3 g (103 mmol) of potassium carbonate and 21.7 g (103 mmol) of dimethyl 4-hydroxyphthalate, the desired product is obtained in the form of orange-coloured crystals (m.p.=65° C.; m=27 g; Y=74%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706725B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-9b468566bda74a27be4e1a0648ec4d38 |
| 出典メモ | uspto-grants-2004_03 |