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Dihexylamine → 4-(N,N-di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dihexylamine | HCID 8920 | — |
| 反応物 | 3,4-Diethoxy-1,2,5-thiadiazole-1,1-dioxide | HCID 11217995 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(N,N-di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole | HCID 22138787 | 72.4% |
反応手順
Dihexylamine (90 mg, 0.48 mmol) was added to a solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (100 mg, 0.48 mmol) in ethanol (5 mL) and the reaction stirred overnight at room temperature. The solvent was removed under reduced pressure and the residue absorbed onto silica gel, and purified by flash column chromatography (silica, hexane:EtOAc 3:1) to yield 4-(N,N-di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole (120 mg, 72%). MS (EI, m/e 345).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07538215B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-9e67ebadc2a440d98db9cb0fd6976dbc |
| 出典メモ | uspto-grants-2009_05 |