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Water → (2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride | HCID 19784336 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine | HCID 19096243 | — |
反応手順
1.75 g of lithium aluminum hydride are added in fractions under a stream of nitrogen to a solution of 4.4 g of the compound from Example 4 in 150 ml of tetrahydrofuran. After stirring for 1 hour, the mixture is hydrolyzed with 1.75 ml of water, 3.5 ml of a 10% (wt/wt) sodium hydroxide solution and 7 ml of water. Filtration through celite, followed by evaporation of the solvent, yields an oily product which is used as it is in the following stage.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242933 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-2e907e16bf72484bb0b4699a8a7a2f7d |
| 出典メモ | uspto-grants-1993_09 |