化工社化工社 化学情報印刷レポート · 研究参考用
2-Iodobenzoic acid → 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Iodobenzoic acid | HCID 6941 | — |
| 反応物 | 2-Chloro-6-ethoxypyridine | HCID 98563 | — |
| 反応物 | 6-Ethoxy-2-hydrazinopyridine | HCID 22320339 | — |
| 反応物 | 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine | HCID 22320358 | — |
| 生成物 | 4-Chloro-1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazolo[3,4-b]quinoline | HCID 22320331 | — |
| 生成物 | 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine | HCID 22320358 | 36% |
反応手順
Following the procedure described in Reference Example 2-4, 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine was prepared from 6-ethoxy-2-hydrazinopyridine which was prepared from 2-chloro-6-ethoxypyridine following the method described in Reference Example 2-2. Subsequently, following the methods described in Reference Example 2-5 and Example 2-1, the title compound was prepared from o-iodobenzoic acid and 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine (36% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949648B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-924538d461a647ff98332d649a44b220 |
| 出典メモ | uspto-grants-2005_09 |