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2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide → N-(4-Chlorophenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide | HCID 587906 | — |
| 反応物 | [1-(Pyridin-4-yl)piperidin-4-yl]methanamine | HCID 10607746 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(4-Chlorophenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide | HCID 12990573 | 24% |
反応手順
Using a similar procedure to that described in Example 8, Part B, 2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide (125 mg, 0.47 mmol), 1-(4-pyridyl)piperidin-4-ylmethylamine (90 mg, 0.47 mmol), and triethylamine (0.07 mL) yielded 40 mg (24%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710057B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-16505e1677fa44da9c425c98f1e22133 |
| 出典メモ | uspto-grants-2004_03 |