化工社化工社 化学情報印刷レポート · 研究参考用
Methacryloyl chloride → 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methacryloyl chloride | HCID 13528 | — |
| 反応物 | 5,5,5-Trifluoro-4-(trifluoromethyl)pentane-1,4-diol | HCID 21895362 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 反応物 | HCID 178418348 | HCID 178418348 | — |
| 生成物 | 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate | HCID 18443720 | 76% |
反応手順
The title compound was prepared by method of Example 4, substituting 43 g (0.181 mol) of 1,1,1-trifluoro-2-trifluoromethyl-4-methyl-2,5-pentanediol (2) for 1,1,1-trifluoro-2-trifluoromethyl-2,5-pentanediol (4) and 226 mL (0.362 mol) of methyllithium (1.6M in ether) in lieu of the n-butyllithium, and using 20.7 g (0.199 mol) of methacryloyl chloride, to yield 35 g (76%) of the title compound as a clear colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07767866B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-25977dcb45444e15b2002fb7882159ff |
| 出典メモ | uspto-grants-2010_08 |