化工社化工社 化学情報印刷レポート · 研究参考用
Acryloyl chloride → 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acryloyl chloride | HCID 13140 | — |
| 反応物 | Methacryloyl chloride | HCID 13528 | — |
| 反応物 | 5,5,5-Trifluoro-4-(trifluoromethyl)pentane-1,4-diol | HCID 21895362 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 反応物 | HCID 178418348 | HCID 178418348 | — |
| 生成物 | 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate | HCID 58999836 | 86% |
反応手順
1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate was synthesized according to the method of Example 4 but substituting (a) 60 g (0.25 mol) of 1,1,1-trifluoro-2-trifluoromethyl-4-methyl-2,5-pentanediol (2) for diol (4), (b) 311 mL (0.497 mol) of methyllithium (1.6M in ether) for the n-butyllithium, and (c) 22.3 g (0.248 mol) of acryloyl chloride for the methacryloyl chloride, to yield 58 g (86%) of the title compound as a clear colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07767866B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-93decf45e0204c098bca0e169fb3c16c |
| 出典メモ | uspto-grants-2010_08 |