関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-Methylmethanesulfonamide | HCID 97632 | — |
| 反応物 | Ethyl 6-bromo-1-benzothiophene-2-carboxylate | HCID 13567982 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-((6-bromobenzo[b]thiophen-3-yl)methyl)-N-methylmethanesulfonamide | HCID 67066523 | — |
反応手順
A mixture of the product from Example 76, Part D (0.100 g, 0.382 mmol), N-methylmethanesulfonamide (45.9 mg, 0.421 mmol) and potassium carbonate (0.127 g, 0.918 mmol) in N,N-dimethylacetamide (5 mL). The mixture was stirred at 80° C. for 11 h, cooled to room temperature and partitioned between diethylether and water (3×), dried over mgSO4, filtered and concentrated in vacuo to give the title compound as a colorless waxy solid (0.128 g, quant.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09095590B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-ee456261a9e04869a9d86a93c1de3dcd |
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| 出典メモ | uspto-grants-2015_08 |
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