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Hydrochloric Acid → (E)-1-(5-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| 反応物 | 2-Chloro-5-methyl-pyridine | HCID 581393 | — |
| 反応物 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (E)-1-(5-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736693 | — |
反応手順
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-5-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate-hexane to give the titled compound. MW: 347.85; mp: 245.0-247.0° C.; 1H-NMR (DMSO-d6) δ: 8.66 (1H, d, J=1.8 Hz), 8.19 (1H, d, J=16.1 Hz), 8.08 (1H, dd, J=8.1, 2.1 Hz), 7.87 (1H, d, J=8.8 Hz), 7.76 (1H, d, J=8.1 Hz), 7.71-7.66 (2H, m), 7.57-7.52 (2H, m), 7.49-7.44 (4H, m), 7.19 (1H, d, J=16.1 Hz), 2.50 (3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713482B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-32f27ba2bba54cb4a6d3453dbd85a274 |
| 出典メモ | uspto-grants-2004_03 |