化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (4-Chloro-3-nitrobenzyl)amine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide | HCID 19879857 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (4-Chloro-3-nitrobenzyl)amine hydrochloride | HCID 18796739 | 221.7% |
反応手順
To a solution of N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide (0.800 g) in methanol (20 mL) was added conc. HCl (2.0 ml). The reaction mass was refluxed for 18 h. Excess solvent was removed under vacuum to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 7.18 (s, 1H), 7.35 (s, 1H), 7.52 (s, 1H), 7.86 (s, 2H), 8.28 (s, 1H), 8.72 (br s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09096545B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-34c81e3d4f8c47948ae2c6a9421f22d6 |
| 出典メモ | uspto-grants-2015_08 |