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Triethylamine → HCID 57876039、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | (2-Bromoethyl)cyclohexane | HCID 15440 | — |
| 反応物 | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| 反応物 | 1-Methylpiperidin-4-one hydrochloride | HCID 12210057 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 57876039 | HCID 57876039 | 0.9% |
反応手順
Preparation of the title compound was carried out according to General Method 8. 4-Chlorophenylhydrazine hydrochloride (1 g, 5.5 mmol), 1-bromo-2-cyclohexylethane (0.87 ml, 5.5 mmol), triethyl amine (2.31 ml, 16.6 mmol) and N-methyl-4-piperidone hydrochloride (810 mg, 5.5 mmol) were combined in ethanol (10 ml) to obtain 16 mg of 8-chloro-5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole after purification on silica gel (230-400 mesh) chromatography eluting with acetone-hexane gradient. The free base was converted into its oxalate salt by treatment of oxalic acid (1 equiv.) in anhydrous THF.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09096591B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-f7391cc9c2684568ae66b70b164d434e |
| 出典メモ | uspto-grants-2015_08 |