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Dimethylformamide dimethyl acetal → 1-(3,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 1-(3,4-Difluorophenyl)ethan-1-one | HCID 123052 | — |
| 生成物 | 1-(3,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one | HCID 63706116 | 84% |
反応手順
The title compound was prepared in 84% yield from 1-(3,4-difluorophenyl)ethanone and DMF-DMA according to the procedure for the preparation of Example 12, part A. 1H NMR (400 MHz, CDCl3): δ 2.93 (3H, s), 3.16 (3H, s), 5.62 (1H, d, J=12.0 Hz), 7.13-7.20 (1H, m), 7.63-7.76 (2H, m), 7.83 (1H, d, J=12.0 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09107916B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-8e532665e6fd4c858cd1d1d1e231ffbc |
| 出典メモ | uspto-grants-2015_08 |