関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 8-Quinolinesulfonyl chloride | HCID 29220 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(Quinoline-8-sulfonamido)benzoic acid | HCID 776645 | 58.4% |
反応手順
To a solution of 4-aminobenzoic acid (10 g, 73 mmol) in 100 mL of anhydrous THF was added pyridine (1.15 g, 146 mmol), and quinoline-8-sulfonyl chloride (20 g, 88 mmol) at 0° C. The resulting mixture was stirred at 70° C. overnight. After filtration, the residue was washed with EtOH and 14 g of title compound was obtained as pure product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09108921B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-ede0bf0528ba4e8186dfcc4f9fff99be |
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| 出典メモ | uspto-grants-2015_08 |
|---|
