関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Methyl 6-(hydroxymethyl)picolinate | HCID 11513809 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 6-(chloromethyl)pyridine-2-carboxylate | HCID 53404482 | 101.4% |
反応手順
SOCl2 (57 g, 0.48 mol) was added to a solution of methyl 6-(hydroxymethyl)picolinate 66 (40.0 g, 0.239 mol) (Chem. Eur. J. 2006, 12, 6393-6402) in dichloromethane (500 mL) at room temperature. The mixture was stirred at 40° C. for 1 h and sat. aq K2CO3 was added to adjust the pH to 9. The mixture was extracted with CH2Cl2 and the combined organics were washed with brine, dried (Na2SO4), and concentrated in vacuo to give 67 (45 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09326986B2 |
|---|
| 出典データセット | uspto-grants-2016_05 |
|---|
| ORD ID | ord-3040965c9beb4b7faa1e882259a44048 |
|---|
| 出典メモ | uspto-grants-2016_05 |
|---|
