化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → 4-(4-Methyl-1-piperazinyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | p-(1-Piperazinyl)phenol | HCID 92467 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | Acetic acid tetrahydrofuran | HCID 23444217 | — |
| 生成物 | 4-(4-Methyl-1-piperazinyl)phenol | HCID 11622486 | 106.4% |
反応手順
4-(piperazin-1-yl)phenol 2 g (11.24 mmol) and formaldehyde 4.5 mL (37% in water, 56 mmol) were suspended in a mixture of THF/AcOH 5/1 and let under stirring at room temperature. After 30 minutes sodium triacetoxyborohydride 4.7 g (22.5 mmol) was added portion-wise. The reaction was let stir a few hours and evaporated down. The crude was purified on silica gel with AcOEt/EtOH/(NH3 7 N in MeOH) 8/2/0.2 to give 2.3 g of pink solid as a free base.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09333205B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-4ec99b628aaf4feb9ef037415756c670 |
| 出典メモ | uspto-grants-2016_05 |