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Dimethylformamide → 5-(4-Fluoro-phenoxy)-isoindole-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-Nitrophthalimide | HCID 6969 | — |
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(4-Fluoro-phenoxy)-isoindole-1,3-dione | HCID 66712629 | 18.6% |
反応手順
A mixture of 5-Nitro-isoindole-1,3-dione (177 g, 0.904 mol), 4-fluoro-phenol (128 g, 1.13 mol), K2CO3 (419 g, 3 mol) and DMF (2 l) was refluxed with stirring for 3 h before the mixture was poured into water (12 l) with stirring. The precipitate formed was isolated by vacuum filtration, washed with water (8 l) and dried in vacuo at 70° C. to give the title compound as a tan powder (43.2 g); 1H NMR (CDCl3) δ=7.79 (d, 1H), 7.57 (br s, 1H), 7.01 to 7.29 (m, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09339527B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-15d359107eb6498fbb5125659c94f977 |
| 出典メモ | uspto-grants-2016_05 |