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Triethylamine → Cbz-aminoglutarimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Amino-2,6-piperidinedione | HCID 134508 | — |
| 反応物 | 1H,3H-furo(3,4-c)pyridine-1,3-dione | HCID 278398 | — |
| 生成物 | Cbz-aminoglutarimide | HCID 67017964 | 17% |
反応手順
With reference to Scheme 4 below, azathalidomide was prepared from aminoglutarimide and commercial pyridine-3,4-dicarboxylic anhydride. Cbz-aminoglutarimide was deprotected by hydrogenolysis with catalyst palladium hydroxide on carbon (10%) to form aminoglutarimide. Pyridine-3,4-dicarboxyic anhydride was refluxed with aminoglutarimide in the presence of triethylamine to yield azathalidomide 11 in the total yield of 17% from Cbz-aminoglutarimide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853253B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-ce699545f7fa4c82baa51d40f8c107be |
| 出典メモ | uspto-grants-2014_10 |