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4-[(5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl)ethynyl]benzoic acid → 4-[(5-Acetoxy-7,8-dihydro-8,8-dimethylnaphth-3-yl)ethynyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[(5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl)ethynyl]benzoic acid | HCID 18314593 | — |
| 反応物 | Ethyl 4-[(5-acetoxy-7,8-dihydro-8,8-dimethylnaphth-2-yl)ethynyl]benzoate | HCID 19962310 | — |
| 生成物 | 4-[(5-Acetoxy-7,8-dihydro-8,8-dimethylnaphth-3-yl)ethynyl]benzoic acid | HCID 19962325 | — |
反応手順
Employing the same general procedure as for the preparation of ethyl 4-[(5-acetoxy-7,8-dihydro-8,8-dimethylnaphth-2-yl)ethynyl]benzoate (Compound 105), 100.0 mg (0.31 mmol) of 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl)ethynyl]benzoic acid (Compound 8) was converted into the title compound (white solid) using 0.08 ml (0.94 mmol) of acetic anhydride and 30 mg (0.16 mmol) of p-toluenesulfonic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05618931 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-92e848217e1c48d4b16f8fd5e84aeed9 |
| 出典メモ | uspto-grants-1997_04 |