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Triethylamine → N-(4,5-Diphenyl-thiazol-2-yl)-4-methyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 反応物 | 2-Amino-4,5-diphenylthiazole | HCID 73222 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-(4,5-Diphenyl-thiazol-2-yl)-4-methyl-benzamide | HCID 3112499 | — |
反応手順
4,5-Diphenyl-thiazol-2-ylamine (50.5 mg, 0.200 mmol) and 4-methyl-benzoyl chloride (30.9 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was subjected to microwave irradiation for 5 minutes at 200° C. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (18.6 mg, 0.0502 mmol, 25.1%). ESI-MS m/z calc. 370.1. found 371.2 (M+1)+ Retention time 4.13 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853415B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-a51524f04b92443e8e667dbfd87938b4 |
| 出典メモ | uspto-grants-2014_10 |