化工社化工社 化学情報印刷レポート · 研究参考用
1-Benzylpiperazine → 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzylpiperazine | HCID 75994 | — |
| 反応物 | Ethyl 7-bromobenzofuran-2-carboxylate | HCID 46738833 | — |
| 生成物 | 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester | HCID 59636745 | — |
反応手順
The compound was prepared according to the procedure disclosed in Example 1a starting from benzylpiperazine (16.1 mL, 92.6 mmol) and 7-bromo-benzofuran-2-carboxylic acid ethyl ester (16.6 g, 61.7 mmol). The product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%). Yield: 14 g (63%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859534B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-c6571e7feed04f2ca443bfcc25b566c3 |
| 出典メモ | uspto-grants-2014_10 |