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Acetic Anhydride → 4'-Bromo-2'-(trifluoromethyl)acetanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 4-Bromo-2-(trifluoromethyl)aniline | HCID 67960 | — |
| 生成物 | 4'-Bromo-2'-(trifluoromethyl)acetanilide | HCID 2773417 | 99.7% |
反応手順
A solution of 2-amino-5-bromobenzotrifluoride (1.623 g, 6.76 mmol, Aldrich) in acetic anhydride (10 mL) was stirred at room temperature for 12 h to produce a white needle precipitate. It was filtered to give 1.840 g (99.7%) of title compound. Mp: 140°-2° C., 1HNMR (CDCl3): δ 2.212 (s, 3H); 7.358 (s, 1H); 7.659 (d, 1H, J =8.7 Hz); 7.726 (d, 1H, J=1.8 Hz); 8.118 (d, 1H, J=8.4 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620979 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-a8f3fd9bf59a4c7c9c40d591d3b3323c |
| 出典メモ | uspto-grants-1997_04 |