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Acetic Anhydride → n-[4-Chloro-3-(trifluoromethyl)phenyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| 生成物 | n-[4-Chloro-3-(trifluoromethyl)phenyl]acetamide | HCID 67676 | 98.5% |
反応手順
A solution of 3-amino-6-chlorobenzotrifluoride (1.045 g, 5.34 mmol, Aldrich) in acetic anhydride (5 mL) was stirred at room temperature for 12 h to produce a white needle precipitate. It was filtered to give 1.250 g (98.5%) of 3-acetamido-6-chlorobenzotrifluoride. 1H NMR (CDCl3): δ 2.193 (s, 3H); 7.420 (d, 1H, J=8.7 Hz); 7.726 (m, 2H), 7.804 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620979 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-c9d2d78dc1bb48ed84a1acb78f622449 |
| 出典メモ | uspto-grants-1997_04 |