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N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide → 4-Chloro-2-nitro-5-(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide | HCID 22318004 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 4-Chloro-2-nitro-5-(trifluoromethyl)aniline | HCID 2737645 | 78% |
反応手順
A mixture of 3-acetamido-6-chloro-4-nitrobenzotrifluoride (780 mg, 2.76 mmol) in concentrated HCl (3 mL) was refluxed overnight and it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 517 mg (78% ) of 3-amino-6-chloro-4-nitrobenzotrifluoride. 1H NMR (CDCl3): δ 6.205 (S, 2H); 7.206 (s, 1H); 8.263 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620979 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-971afb0efd3a4d0d94a318d0837f4da0 |
| 出典メモ | uspto-grants-1997_04 |