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N-Methylmaleimide → 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylmaleimide | HCID 70261 | — |
| 反応物 | Pipecolic acid, (+)- | HCID 736316 | — |
| 反応物 | 3-(5-Bromopyridin-2-yl)prop-2-enal | HCID 86676730 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione | HCID 53492368 | — |
反応手順
A mixture of 820 mg of (E)-3-(5-bromopyridin-2-yl)propenal, 500 mg of D-pipecolinic acid, 430 mg of N-methylmaleinimide and 20 ml of MeCN is boiled at reflux for 2 h. The solvents are removed and the residue is purified by column chromatography (silica gel, ethyl acetate:DCM=3:1). Using this method, 3 pure fractions are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08871798B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-901fab959cda48f9b80c1f553c5a1c17 |
| 出典メモ | uspto-grants-2014_10 |