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5,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one → 5,10-dihydro-5-[(1,5-dimethyl-1,2,5,6-tetrahydro-4-pyridinyl)-carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one | HCID 201327 | — |
| 反応物 | 5,10-dihydro-5[(3-methyl-4-pyridinyl)carbonyl]-11H-dibenzo[b,e][1,4]-diazepin-11-one | HCID 13285863 | — |
| 反応物 | 3-Methylpyridine-4-carbonyl chloride | HCID 13285864 | — |
| 反応物 | Benzo[b][1,4]benzodiazepin-6-one | HCID 19781529 | — |
| 反応物 | Diisopropylether methanol | HCID 21882575 | — |
| 生成物 | 5,10-dihydro-5-[(1,5-dimethyl-1,2,5,6-tetrahydro-4-pyridinyl)-carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 20460470 | — |
反応手順
By reacting 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one with 3-methylisonicotinic acid chloride (m.p. 155°-156° C.) via 5,10-dihydro-5-[3-methyl-4-pyridinyl)carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one, m.p. 223°-224° C. (diisopropylether/methanol) and 5,10-dihydro-5[(3-methyl-4-pyridinyl)carbonyl]-11H-dibenzo[b,e][1,4]-diazepin-11-one methoiodide;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04447434 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-ed1696b1d7f04771a91568d987f79a12 |
| 出典メモ | uspto-grants-1984_05 |