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5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine | HCID 15229363 | — |
| 反応物 | Hydrochloride methanol | HCID 21893726 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride | HCID 20086655 | 89.3% |
反応手順
A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05244908 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-90e3544a7e8d48009be88fd306d4e8e7 |
| 出典メモ | uspto-grants-1993_09 |