関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | tert-Butyl 4-(2-((methanesulfonyl)oxy)ethyl)piperidine-1-carboxylate | HCID 15229596 | — |
| 反応物 | Phthalimide potassium salt | HCID 24194345 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[2-[1-tert-butoxycarbonylpiperidin-4-yl]ethyl]phthalimide | HCID 15851771 | 80% |
反応手順
A mixture of 1-tert-butoxycarbonyl-4-(2-mesyloxyethyl)piperidine (1.20 g) and potassium phthalimide (0.80 g) in N,N-dimethylformamide (15 ml) was stirred at 40° C. for 2 hours. The mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, and dried over magnesium sulfate and evaporated in vacuo to give N-[2-[1-tert-butoxycarbonylpiperidin-4-yl]ethyl]phthalimide (1.12 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05622976 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-834af114af9340198c258f1eb7345cf9 |
|---|
| 出典メモ | uspto-grants-1997_04 |
|---|
