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1-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole | HCID 568011 | — |
| 反応物 | 2-Bromo-1-(5-bromothiophen-2-yl)ethan-1-one | HCID 1988398 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide | HCID 19040880 | 88% |
反応手順
Dissolve 2.46 g (10 mmol) of 2-amino-1-(2-morpholinoethyl)benzimidazole in 120 ml of acetone with heating. Subsequently, add 5-bromo-2-bromoacetylthiophene. After stirring, leave at room temperature for 3 to 4 hours. The 2-amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide precipitate is filtered, washed twice with 20 ml of acetone each time and with ether (20 ml) to obtain 4.7 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05623073 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-983dc768e9024bf4b4b1a009d593d4a6 |
| 出典メモ | uspto-grants-1997_04 |