関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lithium azide | HCID 88163 | — |
| 反応物 | 1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol 5-(4-Methylbenzenesulfonate) | HCID 88337105 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,4-Anhydro-5-azido-5-deoxy-2-S-[(4-methoxyphenyl)-methyl]-2-thio-L-arabinitol | HCID 131719993 | 32.6% |
反応手順
A mixture of 2.0 g of product from Example 324, 0.460 g of lithium azide and 2 ml of N,N-dimethylformamide is stirred at 70° C. for 65 hours. The reaction mixture is concentrated in vacuo. The residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane) to give 0.454 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05623081 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-5061bb5743e04cedafaf182a0c9038b8 |
|---|
| 出典メモ | uspto-grants-1997_04 |
|---|
