関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 6-(Difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carboxylic acid | HCID 59396155 | — |
| 反応物 | 4,4-Dimethyl amino pyridine | HCID 66592228 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Nitrophenyl 6-difluoromethyloxybenzo[4,5]furo[3,2-c]pyridine-9-carboxylate | HCID 59396153 | — |
反応手順
A mixture of 6-Difluoromethyloxybenzo[4,5]furo[3,2-c]pyridine-9-carboxylic acid (5.5 g, 0.0197 moles), p-nitro phenol (4.1 g, 0.0295 moles), EDCl (5.7 g, 0.295 moles), 4,4-dimethyl amino pyridine (250 mg, 0.00197 moles) in DMF (603.0 mL) was heated to 70-75° C. for 4-5 hours. The residue obtained after removal of solvent under vacuo was triturated with water (50.0 mL) to give intermediate-18 (6.0 mg) as yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07943634B2 |
|---|
| 出典データセット | uspto-grants-2011_05 |
|---|
| ORD ID | ord-da68c2edf9074921a8c1a09097e8558a |
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| 出典メモ | uspto-grants-2011_05 |
|---|
