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Sodium hydride → N-methyl-N-(4-methoxybenzyl)-4-bromophenylsulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | 4-bromo-N-methylbenzene-1-sulfonamide | HCID 101215 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-methyl-N-(4-methoxybenzyl)-4-bromophenylsulfonamide | HCID 8319395 | 97.2% |
反応手順
To a solution of N-methyl-4-bromophenylsulfonamide (2.5 g, 10 mmol) in DMF (20 mL) at room temperature was added in portions NaH (264 mg, 11 mmol). The mixture was stirred for 45 minutes and then p-methoxybenzylchloride (1.49 mL, 11 mmol) was added dropwise. The mixture was stirred for 1 hour, quenched with water and the precipitate which formed was collected by filtration and dried in vacuo at 60° C. to afford 3.6 g (97%) of N-methyl-N-(4-methoxybenzyl)-4-bromophenylsulfonamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624922 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3068433e0adc427c806d76567bf5cb33 |
| 出典メモ | uspto-grants-1997_04 |