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4-Methyl-5-pyrimidinecarboxylic acid → 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methyl-5-pyrimidinecarboxylic acid | HCID 14922219 | — |
| 反応物 | 6-Chloro-7-methoxy-9h-pyrido[3,4-b]indol-8-amine | HCID 21362743 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide | HCID 11176085 | 80% |
反応手順
The desired compound was prepared according to Method A from 6-chloro-7-methoxy-9H-beta-carbolin-8-ylamine and 4-methyl-5-pyrimidine carboxylic acid in 80% yield. 1H-NMR (300 MHz, DMSO-d6): δ 2.75 (s, 3H), 3.92 (s, 3H), 8.19 (d, 1H), 8.41 (d, 1H), 8.50 (s, 1H), 8.96 (s, 1H), 9.20 (s, 1H), 9.25 (s, 1H), 10.63 (s, 1H), 11.67 (s,1H). Retention Time (LC, method: formic acid standard): 0.95 min. MS (M+H+): 368.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07951801B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-c4100b6401c6453f8d2a9dce796bbb8a |
| 出典メモ | uspto-grants-2011_05 |