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Oxdralazine dihydrochloride → 1-(2-Dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxdralazine dihydrochloride | HCID 168701 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 1-(2-(Dimethylamino)ethyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 654521 | — |
| 反応物 | 6-Chloro-9H-beta-carbolin-8-amine | HCID 21362701 | — |
| 生成物 | 1-(2-Dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide | HCID 11773953 | 70% |
反応手順
Prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 1-(2-dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid in 70-80% yield as the di-HCl salt. 1H-NMR (300 MHz, D2O): δ 2.97 (dd, 1H), 3.03 (s, 6H), 3.08 (dd, 1H), 3.51 (t, 2H), 3.76-3.89 (m, 3H), 3.95 (dd, 1H), 4.01 (dd, 1H), 7.75 (d, 1H), 8.24 (d, 1H), 8.45 (dd, 1H), 8.52 (dd, 1H), 9.10 (bs, 1H). Retention Time (LC, method: ammonium acetate standard): 0.99 min. MS (M+H+): 400.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07951801B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-f65907af9bcd4ee1a0be32454d9a9347 |
| 出典メモ | uspto-grants-2011_05 |