化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → (R*,S*)-(+/-)-5-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Propanedioic acid, 2,2-dibromo-, 1,3-diethyl ester | HCID 69427 | — |
| 反応物 | (R*,S*)-(+/-)-5-(3-chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolidinone | HCID 67823889 | — |
| 触媒 | Propanedioic acid, 2,2-dibromo-, 1,3-diethyl ester | HCID 69427 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (R*,S*)-(+/-)-5-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester | HCID 15669208 | 66.1% |
反応手順
A mixture of 0.8 g of the above oxazolidinone, 0.74 g of diethyl dibromomalonate, 1.2 g of anhydrous potassium carbonate and 20 ml of acetone are stirred overnight with the addition of a few drops of diethyl dibromomalonate. The mixture is filtered, washed with acetone and the combined filtrate and wash are evaporated to a yellow oil. The oil is purified by flash chromatography, eluting with 5 percent acetone in toluene. The pure fractions are combined and evaporated, giving 766 mg of (R*,S*)-(±)-5-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05245053 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-463370cd2f4149d4a74c16289bb0ce5f |
| 出典メモ | uspto-grants-1993_09 |