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Acetonitrile → Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| 反応物 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 生成物 | Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate | HCID 66980031 | — |
反応手順
Ethyl piperidine-4-carboxylate (100 mg) was treated with 2-chloro-6-methoxyquinoline (Intermediate 1) (90 mg) in MeCN (0.8 mL) and TEA (100 mg) in a sealed tube at 180° C. for 6 h in a microwave reactor. After aqueous work-up with EtOAc and column purification, eluting with EtOAc/hexane, ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate (90 mg) was afforded as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09433618B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-550c1e91025842e7bcb55db1293d04a9 |
| 出典メモ | uspto-grants-2016_09 |