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2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide → 2-(2-Bromo-cyclopent-2-enyl)-ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide | HCID 21986069 | — |
| 反応物 | Lithiumtriethylborohydride | HCID 23664628 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-Bromo-cyclopent-2-enyl)-ethanol | HCID 21986094 | 58% |
反応手順
2-(2-Bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide (Intermediate FOUR1) (1.93 g, 8.3 mmol) in THF (50 mL) was reacted with lithium triethylborohydride (19 mL, 1 M in THF) at 0° C. for 1 h. The mixture was treated with an aqueous work-up and the resultant alcohol was purified by column chromatography to give 0.92 g of 2-(2-bromo-cyclopent-2-enyl)-ethanol Intermediate FIVE1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063087B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-32e1c1c926c54f50a03463db09ce9584 |
| 出典メモ | uspto-grants-2011_11 |