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2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-carboxylic acid → 2,2-Dimethyl-2,3-dihydro-benzofuran-7-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-carboxylic acid | HCID 2795469 | — |
| 反応物 | ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone | HCID 66998654 | — |
| 生成物 | 2,2-Dimethyl-2,3-dihydro-benzofuran-7-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide | HCID 25183718 | — |
反応手順
prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,2-Dimethyl-2,3-dihydro-benzofuran-7-carboxylic acid. LC-MS (basic): tR=0.97 min; [M+H]+=502.4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063099B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-50d6528798614828b472b6266776714c |
| 出典メモ | uspto-grants-2011_11 |