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1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid → 2-Ethyl-5-methyl-2h-pyrazole-3-carboxylic acid{(1s,2s,5r)-3-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid | HCID 2743794 | — |
| 反応物 | [2-Amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,2S,5R)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone | HCID 86644211 | — |
| 生成物 | 2-Ethyl-5-methyl-2h-pyrazole-3-carboxylic acid{(1s,2s,5r)-3-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide | HCID 25182832 | — |
反応手順
prepared by reaction of [2-Amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,2S,5R)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid. LC-MS (basic): tR=0.76 min; [M+H]+=469.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063099B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-13f21785f9fe486dbcba3064a650ecbe |
| 出典メモ | uspto-grants-2011_11 |